Far Infrared Studies

Since our inception we have made it a point to present the latest Far Infrared (FIR) Studies and research to our customers and medical and healthcare professionals alike. We realized from personal experience that the internet can be filled with vastly contradictory information; and unfortunately, even down right out lies. Which is why we at 1-844-Biomats felt compelled to provide real and scientific backed relevant research & information. We hope that this will clear up the mystery and half-truths that you have encountered on your journey to better understand the true benefits of Far Infrared.

If you have knowledge of more current research that is backed by standard scientific documentation and would like us to included that so others can be better informed.  Please let us know and we will review the information and if accurate will include it for others to benefit from its content.


Arthritis & Far Infrared (FIR)

Far Infrared (FIR) Therapy for Rheumatoid Arthritis & Ankylosing

Abstract:
To study the effects of Far infrared (FIR), a form of total-body hyperthermia in patients with rheumatoid arthritis and ankylosing spondylitis patients were treated for a 4-week period with a series of eight Far infrared (FIR) treatments. Seventeen rheumatoid arthritis patients and 17 ankylosing spondylitis patients were studied.

Infrared was well tolerated, and no adverse effects were reported, no exacerbation of disease. Pain and stiffness decreased clinically, and improvements were statistically significant (p < 0.05 and p < 0.001 in rheumatoid arthritis and ankylosing spondylitis patients, respectively) during a Far Infrared session. Fatigue also decreased. Both rheumatoid arthritis and ankylosing spondylitis patients felt comfortable on average during and especially after treatment. In the rheumatoid arthritis and ankylosing spondylitis patients, pain, stiffness, and fatigue also showed clinical improvements during the 4-week treatment period, but these did not reach statistical significance. No relevant changes in disease activity scores were found, indicating no exacerbation of disease activity.

Conclusion:
In conclusion, infrared treatment has statistically significant short-term beneficial effects and clinically relevant period effects during treatment in rheumatoid arthritis and ankylosing spondylitis patients without enhancing disease activity. Far infrared (FIR) Sauna has good tolerability and no adverse effects.

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Far Infrared (FIR) Therapy for Allergic Rhinitis

Abstract:
“During the period of Far Infrared (FIR) therapy, the symptoms of eye itching, nasal itching, nasal stuffiness, rhinorrhea and sneezing were all significantly improved. Smell impairment was not improved until after the last treatment. No obvious adverse effect was observed in the patients during treatment and follow-up.

Conclusion:

We concluded that FIR therapy could improve the symptoms of Allergic Rhinitis and might serve as a novel treatment modality for Allergic Rhinitis.
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Far Infrared (FIR) Therapy Anti–Inflammatory Effect

Far infrared therapy inhibits vascular endothelial inflammation via the induction of heme oxygenase-1.

Abstract:
In this study, it was evaluated whether there is an interaction between Far Infrared radiation and HO-1 in regulating vascular inflammation.
Conclusions:
These results demonstrate that Far Infrared (FIR) therapy exerts a potent anti-inflammatory effect via the induction of HO-1. The ability of Far Infrared (FIR) therapy to inhibit inflammation may play a critical role in preserving blood flow and patency of AVFs in haemodialysis patients.

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Far Infrared(FIR)- Anti-Oxidant Effect

Antioxidative Effect of Far-Infrared Radiation in Humans

Abstract:
The antioxidative effect of far-infrared radiation (FIR) in human was evaluated by half maximal inhibitory concentration of blood against superoxide anions. All samples ranging from 18 to 30 years old were grouped into sympathetic, parasympathetic, sympathetic plus parasympathetic and the control group. The ability of antioxidation of blood from the subjects was measured with an ultraweak chemiluminescence analyzer. According to the results, the level of superoxide anions was decreased in sympathetic, parasympathetic, and sympathetic plus parasympathetic group, while that in the control group was increased.

Conclusion:
This suggested that theFar Infrared (FIR) radiation performed a significantly antioxidative effect by defending human from oxidative damage of superoxide anions in blood. This may probably be achieved by increasing SOD concentration and/or increasing heart rate variability.

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Cancer and Whole Body Hyperthermia

Abstract:
A new high intensity focused ultrasound (HIFU) apparatus (Sonic CZ901 : Mianyang Sonic Electronic Ltd, China) was installed in our hospital last December. The device has been used 20 times in 12 advanced cancer patients, and some results concerning the use of HIFU ablation and Whole body hyperthermia (WBH) via far-infrared equipment (RHS 7500 : Enthermics Medical Systems, USA) can be reported. The first patient had pharyngeal cancer (20y.o, F) with lung and multiple liver metastases. The lung tumor shrank after WBH (weekly treatments, for a total of 4 treatments) and the liver tumor was clearly reduced by HIFU treatment. A second patient who received the combined treatment had a neck tumor with bone metastasis (65y.o, M). The patient received WBH after HIFU treatment for a 7th rib bone metastasis. After 10 days, the neck tumor developed internal necrosis, and ruptured. CT imaging showed necrotic changes focused in the neck tumor and also the rib bone metastasis.

Conclusion:
These results may be a positive indication for HIFU treatment, but there are other positive indications for the primary organ tumour. This new thermal combination therapy appears to have great promise.

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Cancer, far-infrared radiation (FIR) heat shock protein (HSP) 70A

Abstract:
We developed a tissue culture incubator that can continuously irradiate cells with far-infrared radiation (FIR) of wavelengths between 4 and 20 microm with a peak of 7-12 microm, and found that FIR caused different inhibiting effects to five human cancer cell lines, namely A431 (vulva), HSC3 (tongue), Sa3 (gingiva), A549 (lung), and MCF7 (breast). Then, in order to make clear the control system for the effect of FIR, the gene expression concerned to the inhibition effect by FIR were analyzed. In consequence, basal expression level of HSP70A mRNA was higher in A431 and MCF7 cells than in the FIR-sensitive HSC3, Sa3, and A549 cells. Also, the over expression of HSP70 inhibited FIR-induced growth arrest in HSC3 cells, and an HSP70 siRNA inhibited the proliferation of A431 cells by irradiation with FIR. These results indicate that the effect of a body temperature range of FIR suppressing the proliferation of some cancer cells is controlled by the basal expression level of heat shock protein (HSP) 70A.

Conclusion:
This finding suggested that Far Infrared Rays (FIR) should be very effective medical treatment for some cancer cells which have a low level of HSP70. Still more, if the level of HSP70 in any cancer of a patient was measured, the effect of medical treatment by FIR can be foreseen for the cancer.

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Breast Cancer and Far Infrared (FIR)

Evidence that irradiation of far-infrared rays inhibits mammary tumour growth in SHN mice.

Abstract:
To evaluate the effect of irradiation of far infrared rays (FIR), the growth of spontaneous mammary tumours of SHN mice was compared among 3 groups: the control was kept until the end of experiment on the normal rack in the absence of FIR and Experimental group I was constantly exposed to FIR. Experimental group Il was raised as the control followed by movement to the FIR rack after mammary tumour appearance. While there was little difference between the control and Experimental group I in mammary tumour growth for 16 days, Experimental group II was significantly lower than the control in this parameter. Furthermore, the percentage of rapidly growing tumours showing greater than 200% of growth rate was apparently lower in Experimental group II. Associated with this, epidermal growth factor receptor expression in mammary tumours, anterior pituitary weight and serum leptin level were significantly decreased in Experimental group II.

Conclusion:
The findings suggest that whole-body FIR irradiation at ambient temperature could be a possible way of a hyperthermic therapy for tumours.

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Breast Cancer and Hyperthermia with Far Infrared (FIR)

Inhibition by whole-body hyperthermia with far-infrared rays of the growth of spontaneous mammary tumours in mice.

Abstract:
To evaluate possible therapeutic benefits of irradiation with far-infrared rays (FIR) on breast cancer, we examined combined effects of the chronic exposure to FIR at ambient temperature (26.5-27.5 degrees C) and the whole-body hyperthermia induced by FIR (WBH) (35-41 degrees C) on the growth of spontaneous mammary tumours of mice. A high mammary tumour strain of SHN virgin mice born on the normal rack or FIR rack were maintained on the respective racks until mammary tumour appearance. When the mammary tumour size reached approximately 7 mm, some mice in each group received no further treatment (Control and FIR groups, respectively) and the remaining mice received 3 hours of WBH each of 5 consecutive days (C + WBH and FIR + WBH groups, respectively). There was little difference between the control and FIR groups in the tumour growth over 10 days of examination. On the other hand, the tumour growth was inhibited significantly in both C + WBH and FIR + WBH groups and the degree of inhibition was similar. The data confirmed that the chronic exposure to FIR at ambient temperature has little effect on the growth of spontaneous mammary tumours in mice.

Conclusion:
Whole-Body Hyperthermia with FIR, however, strongly inhibited the tumour growth without deleterious side-effects, while chronic FIR irradiation itself again had little effect in this process. This Whole-Body Hyperthermiaregimen may serve as a useful animal model for long-term studies of a noninvasive treatment of breast cancer.

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Breast Cancer Cells & Far Infrared (FIR)

Far Infrared Ray Irradiation Induces Intracellular Generation of Nitric Oxide in Breast Cancer Cells

Abstract:
Far infrared radiation has been used in many health-promoting applications, but the cellular mechanisms have not been elucidated. We investigated the influence of non-thermal-enhanced Far infrared radiation for generating nitric oxide (NO) in breast cancer cells. We used MCF-7 breast cancer cells treated with FIR irradiation or left untreated, and measured the inducible NO concentrations using the DAF-FM diacetate (4-amino-5-methylamino-2’,7’-difluorofluorescein) technique. Mean fluorescence intensities of DAF-FM assays from different breast cancer cells showed progressive and cumulative increases in NO with Far infrared irradiation. Significant inductions of NO synthesis in breast cancer cells were observed both during and after Far infrared irradiation. Including data from a literature review, we discuss possible therapeutic roles of Far infrared radiation for breast cancers through the induction of NO generation.

Conclusion:
‘‘Nitric Oxide seems to act in vitro as an inhibitory factor of carcinogenesis in Human breast Cancer cells.’’- Reveneau et al 1999.

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Colon Cancer & Far Infrared (FIR)

Antitumor effect of whole body (Far Infrared) hyperthermia with alpha-galactosylceramide in a subcutaneous tumor model of colon cancer.

Abstract:
AIM:
Whole body hyperthermia (WBH) has been used clinically as an adjunct to radio- and chemotherapy in patients with various cancers. Recently, it has been reported that an activation of the immune system has recently been reported as a possible contributor to the therapeutic effects of WBH. Conversely, the glycolipid alpha-galactosylceramide (alpha-GalCer) is recognized by natural killer (NK) T cells together with the monomorphic MHC-like antigen, CD1d, in mice and humans. This study investigated the antitumor effects of WBH combined with alpha-GalCer in a mouse subcutaneous tumor model of colon cancer.

Methods:
Colon26 cells were inoculated subcutaneously into male BALB/c mice to establish subcutaneous tumor. Colon26-bearing mice were treated with Whole body hyperthermia using far infrared rays three times/week. Rectal temperature was maintained for 60 min at 41 degrees C. In some experimental groups, alpha-GalCer was intraperitoneally injected before WBH. We investigated the therapeutic effects of WBH, alpha-GalCer and combined therapy.

Results:
(1) Compared with controls, Whole Body Hyperthermia alone resulted in significant inhibition of tumor growth. (2) No inhibitory effect on tumor growth was seen with alpha-GalCer. (3) The combination of WBH and alpha-GalCer showed significant inhibition of tumor growth and prolongation of survival. (4) Serum IFN-gamma increased after 3 h and returned to basal levels by 24 h after alpha-GalCer administration. (5) CTL activity was enhanced following combination therapy with WBH and alpha-GalCer.

Conclusion:
Whole Body Hyperthermia showed antitumor effects in a mouse subcutaneous tumor model of colon cancer. Addition of alpha-GalCer increased the efficacy of Whole Body Hyperthermia, probably via enhancement of immune response.

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Far Infrared (FIR) & Liver Cancer Cells

Non-Thermal Effects of Far-Infrared Ray (FIR) on Human Hepatocellular Carcinoma Cells HepG2 and their Tumours

Abstract:
Background: We developed a cell culture CO2 incubator and a mice rack that can continuously irradiate cells or murine with Far Infrared Ray. Our goal is to make clear the non-thermal effect of FIR on HepG2 with these instruments morphologically.

Methods:
By using them, in vitro, we examined the proliferation of cultured HepG2 cells with hematocytometer, BrdU assay, WST-1 assay, HE staining, Toluidine blue staining and microarray studies. And in vivo, we measured the tumors, observed the sections by IHC, DAPI staining with light microscopes and performed microarray studies.

Results:
Proliferation of HepG2 cells were suppressed (e.g., cell count declined by 34% after 10 days of Far Infrared Ray irradiation), tumor volumes reduced by 86% after 30 days of Far Infrared Ray irradiation, mRNA of Vascular Endothelial Growth Factor (VEGF) decreased by 48%, vascular area in cross sections from the tumors decreased 60% compared with the control. More frequent properties in apoptosis were observed by TUNEL and DAPI staining in FIR-treated groups. Body weight of mice increased compared with the control. Oxydation and Reduction (Redox) reactions by H+ (proton and electron)/O2- (a kind of Reactive Oxygen Species (ROS)) were induced by FIR.

Conclusions:
These results clarified that Far Infrared Rays inhibited the proliferation of HepG2 at non-thermal circumstances (at 25±0.5, 37±0.5°C). Far Infrared Rays will serve as a tool against diseases induced by HepG2

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